Purification of Human Serum Paraoxonase and Effect of Acetylsalicylic Acid on Paraoxonase Activity
نویسندگان
چکیده
منابع مشابه
Purification of Human Serum Paraoxonase-1
Membrane proteins play key roles in fundamental biological processes, such as transport of molecules, signalling, energy utilization, and maintenance of cell and tissue structures. Serum paraoxonase (PON1, EC 3.1.8.1.) is a protein of 354 amino acids with a molecular mass of 43 kDa is a high density lipid (HDL) associated, calcium-dependent enzyme whose 3D structure, active site residues and ph...
متن کاملEffects of static and electromagnetic fields on human serum paraoxonase-1 activity in vitro
Introduction: In recent years the relationship between electromagnetic fields and coronary artery disease is attracted a considerable attention. Low density lipoprotein (LDL) oxidation is the initial step in the development of atherosclerosis. Paraoxonase1 (PON1) protects LDL and High density lipoprotein (HDL) against oxidative processes, thus preventing the formation of atherogenic (oxidized-L...
متن کاملBaculovirus-mediated expression and purification of human serum paraoxonase 1A.
Human paraoxonase 1 (hPON1) is a lipid-associated enzyme transported on HDL. There is considerable interest in hPON1 because of its putative antioxidative/antiatherogenic properties. We have created a recombinant baculovirus (BV) to generate hPON1A in large quantities for structure-function studies and here describe the method for production and isolation of the enzyme. A high level of recombin...
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چکیده ندارد.
15 صفحه اولStudies on human serum paraoxonase/arylesterase.
The complete amino acid sequence of human serum paraoxonase/arylesterase and the DNA sequence coding for that protein have recently been determined in two independent laboratories. There is now considerable evidence that the esterase exists in two genetically determined allozymic forms, and these A and B allozymes possess both paraoxonase and arylesterase activities. The B-type esterase has rel...
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ژورنال
عنوان ژورنال: Pharmaceutical Biology
سال: 2008
ISSN: 1388-0209,1744-5116
DOI: 10.1080/13880200802055834